A new study has confirmed a significant relationship between coronary artery disease and Alzheimer's disease, highlighting potential targets for further investigation into the origins of both diseases.
The research team from Edith Cowan University in Australia examined large genetic datasets to search for Shared genes or genetic variations may increase the risk of Alzheimer's disease, coronary artery disease, and concentrations of triglycerides and lipoproteins (fats that have been implicated in the development of Alzheimer's disease and heart disease).
Observational evidence of links between Alzheimer's disease and coronary artery disease has suggested that both conditions may They share a deeper reason. By including fats in this latest investigation, the team hopes to get a more detailed picture of how heart health and brain health are linked.
“There is significant evidence from observational and other studies to support the existence of Link between these conditions However, the complex biological mechanisms of Alzheimer's disease are poorly understood, and its relationship to lipids and features of coronary artery disease remains unresolved.
The results of the analysis indicate that some common genes play a role in Alzheimer's disease and its features. Heart diseases, such as angina and heart attacks, and increased serum lipid concentrations, including cholesterol and triglycerides.
However, the data do not support a causal link, meaning that the genetic factors behind Alzheimer's disease also cause heart disease or vice versa. What is shown is that these shared genes can increase the risk of developing both types of diseases.
This means that scientists now have many new biological pathways to investigate when it comes to understanding the root causes of both Alzheimer's and heart disease.
Kirby adds: “Our study used a genetic approach to investigate the complex relationships of these comorbid conditions, providing new insights into the common biological underpinnings of these conditions.”